• Description
• OEM Platforms
• Modular Units

Description
Combining LC with MS presents an enormous range of possibilities for sample analysis. LC offers the ability to separate almost any mixture, and MS offers extremely sensitive detection along with qualitative power for target analyte identification. LC–MS creates an efficient analysis technique to eliminate a two-step method for obtaining comprehensive data on an unknown sample. For example, the separated sample emerging from the column can then be identified further with the data from the mass spectrometer. A switching platform can help make a working combination of the two techniques. An example of an automated LC–MS system consists of Rheodyne's Double Three-Way Diverter in-line with an autosampler, a column (LC system), and the mass spectrometer (MS system).

The Double Three-way Diverter operates to divert undesired portions of the sample from the LC system to waste before the sample enters the MS. This diversion removes the unwanted portion of the sample from the entire system and keeps non-volatile salts away from the mass spectrometer. Nonvolatile salts in the mobile phase can quickly degrade the performance of a mass spectrometer should they enter the high vacuum region. Even if the mobile phase is free of nonvolatile salts, a sample may contain salts. Since any salts present in the sample should remain in the unretained portion, switching the column effluent away from the mass spectrometer as the unretained portion emerges from the column is a good way to keep mass spectrometer maintenance to a minimum. The illustration shows the undesired portion of the sample diverted to waste in Position A, and the sample flow travels first through the LC system and then the MS system in Position B.

OEM Platforms
Rheodyne offers a variety of different platforms for your LC–MS needs. Rheodyne's Mass Rate Attenuator (MRA™) is included in this suite of products. The MRA is an active splitting device that provides user programmable LC–MS split ratios from 100:1 to 100,000:1 in a single device. With this tool, users are provided with accurate and consistent split ratios that are independent of changes in temperature, mobile phase viscosity, and tubing length.

The table below contains a list of platforms for LC–MS with direct links to other literature that will provide you with more detailed information. If you do not see the platform that suits your application, please contact Rheodyne to discuss your LC–MS needs.

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Modular Units
Rheodyne manufactures a variety of self-contained, electrically operated modular units for hyphenated techniques. The following table lists modular units for these applications. Links to specification sheets and a product line bulletin provide more detailed information.

• Contact Rheodyne for assistance in locating a unit that meets your needs.
• Click here for a list of Distributors.

Note. You will need Acrobat Reader to view these files (click to open or right-click and select "Save Target As" to download).